d.3. Bone Acidic Glycoprotein-75 and Dentin Matrix Protein-1Another sialoprotein originally isolated from rat bone has an apparent molecular weight of ∼75 kDa and hence is called bone acidic glycoprotein-75 (BAG-75) [424–426]. This protein is heavily glycosylated and contains 7% sialic acid and 8% phosphate. Thirty percent of the residues in this protein are acidic in nature.

The main issue concerning cancer therapy is the selective targeting of cancer cells. One of the targeting strategies being investigated is using a tumor stimuli-sensitive delivery system that depends on the shared tumor physiological imbalances, which mainly include hypoxia, excessive expression of certain enzymes, tumor acidosis, and redox imbalance.

Briefly describe the genetically altered charge modification utilized to enhance the electrochemical partitioning of a β-galactosidase and T4 lysozyme in aqueous two-phase systems (Luther and Glatz, 1994).

Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences/Key Laboratory of Plant Nutrition and Fertilizer, Ministry of Agriculture, Beijing 100081, China

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