Nitrogen (N), phosphorus (P), sulfur (S), zinc (Zn), and iron (Fe) are some of the vital nutrients required for optimum growth, development, and productivity of plants. The deficiency of any of these nutrients may lead to defects in plant growth and decreased productivity. Plant responses to the deficiency of N, P, S, Fe, or Zn have been studied mainly as a separate event, and only a few reports discuss the molecular basis of biological interaction among the nutrients. Macro-nutrients like N, P, and/or S not only show the interacting pathways for each other but also affect micro-nutrient pathways. Limited reports are available on the investigation of two-by-two or multi-level nutrient interactions in plants. Such studies on the nutrient interaction pathways suggest that an MYB-like transcription factor, phosphate starvation response 1 (PHR1), acts as a master regulator of N, P, S, Fe, and Zn homeostasis. Similarly, light-responsive transcription factors were identified to be involved in modulating nutrient responses in Arabidopsis. This review focuses on the recent advances in our understanding of how plants coordinate the acquisition, transport, signaling, and interacting pathways for N, P, S, Fe, and Zn nutrition at the molecular level. Identification of the important candidate genes for interactions between N, P, S, Fe, and/or Zn metabolic pathways might be useful for the breeders to improve nutrient use efficiency and yield/quality of crop plants. Integrated studies on pathways interactions/cross-talks between macro‐ and micro-nutrients in the agronomically important crop plants would be essential for sustainable agriculture around the globe, particularly under the changing climatic conditions.

To be able to grow, develop, and produce at their best, plants must have specific elements or compounds called plant essential nutrients.A plant that lacks an essential nutrient cannot complete its life cycle—the seed may not germinate; the plant may not be able to develop roots, stems, leaves, or flowers properly; or it may not be able to produce seeds to create new plants. Often the plant itself will die.However, having too much of a nutrient can harm and even kill plants. For example, having too much nitrogen can cause a plant to grow more leaves but less or no fruit. Too much manganese can make the leaves turn yellow and eventually die. And excess boron can kill a plant.You can save money and effort—and even your plants— if you know what and how much to give your plants. The plants will be healthier and more productive if you give them what they need—no more and no less.

In the quest for increased yield, it becomes essential to learn and understand the details of soil fertility. High-yielding traits, more sophisticated fertilizer technologies and increased understanding of the role that soil microorganisms play have made fine-tuning soil fertility easier, but at the same time, more complex.

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